乳果糖
医学
肝性脑病
胃肠病学
内科学
灌肠
醋酸
便秘
生物化学
肝硬化
化学
作者
Ana de Lorenzo-Pinto,Raquel García-Sánchez,Almudena Lorenzo-Salinas
标识
DOI:10.17235/reed.2017.5106/2017
摘要
The administration of lactulose enemas instead of or in combination with oral lactulose is common practice in patients with hepatic encephalopathy. Lactulose is a non-absorbable disaccharide that is catabolized by the bacterial flora to short chain fatty acids (e.g., lactic acid and acetic acid) which lower the colonic pH. This pH favors the formation of non-absorbable NH4+ from NH3, trapping NH4+ in the colon and thus reducing plasma ammonia concentrations. Lactulose therapy is considered as a first-line treatment and can be administered both orally and rectally.
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