自噬
粒体自噬
成骨细胞
细胞生物学
破骨细胞
骨吸收
骨细胞
骨细胞
化学
骨重建
平衡
线粒体
生物
内分泌学
生物化学
细胞凋亡
体外
作者
Jyotirmaya Behera,Jessica Ison,Ashish Tyagi,Gabriel Mbalaviele,Neetu Tyagi
出处
期刊:Life Sciences
[Elsevier]
日期:2022-07-01
卷期号:301: 120595-120595
被引量:16
标识
DOI:10.1016/j.lfs.2022.120595
摘要
Autophagy is a highly evolutionarily conserved process in the eukaryotic cellular system by which dysfunctional organelles are selectively degraded through a series of processes of lysosomal activity and then returned to the cytoplasm for reuse. All cells require this process to maintain cellular homeostasis and promote cell survival during stress responses such as deprivation and hypoxia. Osteoblasts and osteoclasts are two cellular phenotypes in the bone that mediate bone homeostasis. However, an imbalance between osteoblastic bone formation and osteoclastic bone resorption contributes to the onset of bone diseases. Recent studies suggest that autophagy, mitophagy, and selective mitochondrial autophagy may play an essential role in regulating osteoblast differentiation and osteoclast maturation. Autophagic activity dysregulation alters the equilibrium between osteoblastic bone creation and osteoclastic bone resorption, allowing bone disorders like osteoporosis to develop more easily. The current review emphasizes the role of autophagy and mitophagy and their related molecular mechanisms in bone metabolic disorders. In the current review, we emphasize the role of autophagy and mitophagy as well as their related molecular mechanism in bone metabolic disorders. Furthermore, we will discuss autophagy as a target for the treatment of metabolic bone disease and future application in therapeutic translational research.
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