压电
材料科学
信号(编程语言)
悬臂梁
检出限
电压
光电子学
纳米技术
化学
电气工程
计算机科学
色谱法
复合材料
工程类
程序设计语言
作者
Ya‐Wen Zhang,Feng Shi,Chenguang Zhang,Xin Sheng,Yunhao Zhong,Hui Chong,Zhanjun Yang,Chengyin Wang
标识
DOI:10.1016/j.cclet.2022.07.043
摘要
In this article, we used the self-excitation and self-inductance characteristics of polyvinylidene fluoride (PVDF) piezoelectric materials, combined with the powerful signal processing and calculation analysis capabilities of integrated circuits, for the first time to explore a set of microcantilever sensor "readout system" without additional driver (self-driving) and can realize self-sensing external signal (self-sensing). It was successfully applied to the unlabeled detection of avian influenza virus (AIV) H9N2. The specific force of the antigen-antibody complexes on the surface of the microcantilever leads to the change of the stress of the cantilever, which drives the constructed detection device, and does not require an additional excitation source to drive it, that is, the self-driving part. At the same time, due to the movement of piezoelectric charges in the film caused by the positive piezoelectric effect of the PVDF film, self-inductive charges are generated on the surface of the sensor dielectric. The charge signal is converted into a voltage signal, and the sensing part is completed, that is, self-sensing. The immunosensor has a linear range of 100-1000 ng/mL with a detection limit of 2.9 ng/mL. The method will also open up a new avenue for the detection of other analytes based on antigen-antibody responses.
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