纳米载体
免疫系统
多酚
化学
药物输送
癌细胞
单宁酸
免疫检查点
药品
细胞凋亡
药理学
癌症研究
癌症
纳米技术
生物化学
免疫疗法
材料科学
免疫学
生物
抗氧化剂
遗传学
有机化学
作者
Jiajia Xiang,Yifan Zhang,Xin Liu,Quan Zhou,Ying Piao,Shiqun Shao,Jianbin Tang,Zhuxian Zhou,Tao Xie,Youqing Shen
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-06-24
卷期号:22 (13): 5615-5625
被引量:21
标识
DOI:10.1021/acs.nanolett.2c02161
摘要
Nanocarriers have been employed extensively to enhance drug delivery efficacy and reduce the side effect. However, carrier materials for drug delivery have challenging aspects, including safety concerns, low drug content, complexity in preparation, and low reproducibility. Herein, we propose a facile, universal, and green preparation way to use natural polyphenols to build platinum nanocomplex with stable structure, proper size, and high Pt content. The nanocomplexes are constructed by metal-polyphenol coordination using natural polyphenols and 1,2-diaminocyclohexane-Pt (II), enabling dual-responsive drug release behavior. For proof of concept, we demonstrate the antitumor activity of the Pt nanocomplex using a representative tannic acid-Pt nanocomplex (denoted as PTI). PTI can induce intensive tumor cell apoptosis, trigger immunogenic cell death (ICD), remarkably promote cytotoxic T lymphocytes (CTLs) infiltration in tumors, and significantly reduce immunosuppression of the tumor microenvironments, thus stimulating potent antitumor immune responses and showing effective antitumor activity by synergizing immune checkpoint blockade (ICB) therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI