前药
癌症治疗
药品
癌症治疗
刺激(心理学)
缺氧(环境)
化学
纳米技术
药理学
组合化学
医学
癌症
材料科学
氧气
心理学
心理治疗师
有机化学
内科学
作者
Chia-Chin Lin,Yixia Liang,Mingyan Guo,Phei Er Saw,Xiaoding Xu
标识
DOI:10.1016/j.mtadv.2022.100266
摘要
Cancer has posed an enormous challenge to human health. To enhance cancer therapy, researchers have constructed the polyprodrug which drug molecules and polymer backbone polymerize to form. In the repeating prodrug units of the polyprodrug, the free drug is connected to the polymer backbone via stimuli-responsive linkages. Polyprodrugs have garnered increasing interest in recent years, due to their promising potential for the protection of drugs, increased drug loading, and systematic release of drugs in reaction to particular triggers. Herein, we present contemporary developments in reduction, pH, hypoxia, reactive oxygen species (ROS), enzymes, and light-responsive polyprodrug within these several decades. We also present the multi-function of polyprodrug triggered by multi-stimulus, before discussing strategies to enhance the targeting, penetration, and uptake of the polyprodrug. Finally, the existing clinical application and prospects of the polyprodrug are proposed.
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