医学
粘液纤维肉瘤
未分化多形性肉瘤
多西紫杉醇
肉瘤
吉西他滨
疾病
化疗
放射科
肿瘤科
内科学
软组织肉瘤
病理
作者
Aimeé M. Crago,Kenneth Cardona,Hanna Koseła-Paterczyk,Piotr Rutkowski
标识
DOI:10.1016/j.soc.2022.03.006
摘要
Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genomically complex tumors commonly diagnosed in the extremities or trunk of elderly patients. They likely represent a spectrum of disease differentiated by myxoid stroma and curvilinear vessels observed in MFS but not in UPS. Limb-sparing surgery is the standard of care although the infiltrative nature of MFS mandates wider resection margins than are necessary for UPS. UPS are conversely associated with high risks of distal recurrence, often prompting recommendations for adjuvant chemotherapy. In both histologies, anthracycline-based therapies or gemcitabine and docetaxel are used to manage advanced disease; immunotherapy may be of benefit in a subset of patients.
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