Mechanisms Underlying Recovery From Postpartum Depression Following Brexanolone Therapy

SEE CORRESPONDING ARTICLE ON PAGE 283 Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral AmygdalaBiological PsychiatryVol. 91Issue 3PreviewBrexanolone (allopregnanolone) was recently approved by the Food and Drug Administration for the treatment of postpartum depression, demonstrating long-lasting antidepressant effects. Despite our understanding of the mechanism of action of neurosteroids as positive allosteric modulators of GABAA (gamma-aminobutyric acid A) receptors, we still do not fully understand how allopregnanolone exerts persistent antidepressant effects. Full-Text PDF