对映选择合成
五元
手性(物理)
材料科学
酒石酸
结晶学
纳米技术
化学
有机化学
催化作用
手征对称破缺
复合材料
对称性破坏
物理
柠檬酸
合金
量子力学
Nambu–Jona Lasinio模型
作者
Chao Zhou,Shaoyang Zhang,Jing Ai,Ping Li,Yanjie Zhao,Baojie Li,Lu Han,Yingying Duan,Shunai Che
标识
DOI:10.1021/acs.chemmater.1c02417
摘要
The enantioselective interactions between cells and chiral materials would be a crucial factor in homochiral organisms. Herein, we report that pure inorganic chiral mesostructured hydroxyapatite films (CMHAPFs) exhibit enantioselectivity in the regulation of cell behaviors. CMHAPFs were fabricated with tartaric acid (TTA) as a symmetry-breaking agent, and five levels of fractal-like chirality existed: primary twisted “nanoneedles” with atomically distorted crystal lattices, secondary “nanoflakes” with a helical arrangement of “nanoneedles”, tertiary “nanoplates” with a helical arrangement of “nanoflakes”, quaternary “nanopetals” with a helical arrangement of “nanoplates”, and quinary “flowers” consisting of helically arranged “nanopetals”. The CMHAPFs synthesized with L-TTA were advantageous in cell adhesion, cell proliferation, and osteogenic differentiation of primary mesenchymal stem cells, whereas the opposite effect was observed in the CMHAPFs synthesized with D-TTA. This enantioselectivity was speculated to be due to the stereo matching between the hierarchical chiral cell surfaces and multilevel chiral mesostructures of CMHAPFs.
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