化学
色胺
串联
吲哚试验
三环
组合化学
基质(水族馆)
立体化学
生物化学
海洋学
地质学
复合材料
材料科学
作者
Xiao-Tong Lin,Cheng Zhao,Da-Ru Wang,Guangcheng Wu,Guo-Shu Chen,Shujie Chen,Hai Ren,Dongsheng Deng,Xu Yibing,Xiaowei Hu,Yun-Lin Liu
标识
DOI:10.1002/adsc.202101232
摘要
Catalytic tandem cyclization of ynamides has attracted considerable interest in organic synthesis because of its atom economy in the rapid formation of polycyclic compounds. However, examples on the construction of pentacyclic spiroindolines are quite scarce. Herein, we described a BiCl3-mediated tandem cyclization reaction of tryptamine-ynamides, which led to the formation of appealing pentacyclic spiroindoline scaffolds in moderate to excellent yields. In addition, such a reaction can lead to the divergent synthesis of tricyclic indole derivatives with moderate yields by engineering substrate structures. The synthetic utility of this methodology has also been demonstrated by further interesting transformations.
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