Craig 2‐Bromo‐Pyridine Synthesis

Abstract The method for preparing 2‐bromo‐pyridine in high yield from 2‐amino‐pyridine is known as Craig 2‐bromo‐pyridine synthesis. The concentrated aqueous solution of sodium nitrite and 2‐amino‐pyridine have been added to a concentrated hydrobromic acid saturated with bromine to obtain optimum yield of 2‐bromo‐pyridine. This reaction has application for the preparation of 2‐bromo‐pyridine and 2‐bromopyrimidine.