斯达
STAT蛋白
车站3
信号转导
细胞生物学
状态4
生物
转录因子
JAK-STAT信号通路
抄写(语言学)
癌症研究
遗传学
基因
受体酪氨酸激酶
语言学
哲学
作者
Mustafa Benekli,Maria R. Baer,Heinz Baumann,Meir Wetzler
出处
期刊:Blood
[American Society of Hematology]
日期:2003-04-15
卷期号:101 (8): 2940-2954
被引量:304
标识
DOI:10.1182/blood-2002-04-1204
摘要
Abstract Signal transducer and activator of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription factors that contribute to signal transduction by cytokines, hormones, and growth factors. STAT proteins control fundamental cellular processes, including survival, proliferation, and differentiation. Given the critical roles of STAT proteins, it was hypothesized that inappropriate or aberrant activation of STATs might contribute to cellular transformation and, in particular, leukemogenesis. Constitutive activation of mutated STAT3 has in fact been demonstrated to result in transformation. STAT activation has been extensively studied in leukemias, and mechanisms of STAT activation and the potential role of STAT signaling in leukemogenesis are the focus of this review. A better understanding of mechanisms of dysregulation of STAT signaling pathways may serve as a basis for designing novel therapeutic strategies that target these pathways in leukemia cells.
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