组织蛋白酶
血管生成
分泌物
细胞内
癌细胞
半胱氨酸
生物
细胞迁移
细胞生物学
癌症
转移
肿瘤进展
蛋白水解酶
细胞
酶
生物化学
癌症研究
遗传学
作者
Mona Mostafa Mohamed,Bonnie F. Sloane
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2006-10-01
卷期号:6 (10): 764-775
被引量:1133
摘要
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post-transcriptional modification. Their localization within intracellular lysosomes often changes during neoplastic progression, resulting in secretion of both inactive and active forms and association with binding partners on the tumour cell surface. Secreted, cell-surface and intracellular cysteine cathepsins function in proteolytic pathways that increase neoplastic progression. Direct proof for causal roles in tumour growth, migration, invasion, angiogenesis and metastasis has been shown by downregulating or ablating the expression of individual cysteine cathepsins in tumour cells and in transgenic mouse models of human cancer.
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