Genetic Variations within Metalloproteinases Impact on the Prophylaxis of Depressive Phases in Bipolar Patients

双相情感障碍 基质金属蛋白酶 心理学 医学 精神科 内科学 临床心理学 认知
作者
Antonio Drago,Barbara Monti,Diana De Ronchi,Alessandro Serretti
出处
期刊:Neuropsychobiology [Karger Publishers]
卷期号:69 (2): 76-82 被引量:8
标识
DOI:10.1159/000356971
摘要

BACKGROUND: The genetic background of the antidepressant response to pharmacological treatment in bipolar disorder (BD) remains elusive. This issue is of primary relevance in that the depressive phases of BD are difficult to treat and they are associated with suicide. AIM: We investigated the role of a set of genetic variations (single-nucleotide polymorphisms) harbored by matrix metalloproteinases (MMPs) as predictors of response to treatment in depressed BD patients. METHODS: 654 BD patients from the publicly available Systematic Treatment Enhancement Program for Bipolar Disorder study were investigated. The outcome was the number of depressive events corrected by the number of times patients were assessed. Clinical and sociodemographic variables were tested as possible stratification factors and included in the analysis if necessary. Genetic predictors were 43 SNPs harbored by 17 MMPs. Imputation, quality check and pruning were conducted according to standards. RESULTS were corrected for multitesting. RESULTS: rs486055 (MMP-10) was associated with the outcome. TT homozygotes had 5.08 ± 3.51 events, CT had 3.47 ± 3.18 and CC had 2.57 ± 2.96 depressive events corrected for the times they had been assessed. The time during which BD patients were observed was not significantly different between the rs486055 genotypes. We found evidence that MMP-10 may be a mediator of the number of depressive phases during BD. Due to the limits of the study including the small-to-medium sample size, the naturalistic design and the possible occurrence of false-positive findings, independent analyses are warranted.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
潘嫄完成签到,获得积分10
刚刚
1秒前
脑洞疼应助Cindy采纳,获得10
1秒前
丁一发布了新的文献求助10
1秒前
1秒前
笑对人生发布了新的文献求助10
2秒前
过氧化氢完成签到,获得积分10
2秒前
2秒前
Felix发布了新的文献求助10
3秒前
3秒前
Evander完成签到,获得积分10
4秒前
Charles发布了新的文献求助10
4秒前
鑫渊完成签到,获得积分10
5秒前
poppy完成签到,获得积分10
6秒前
852应助juju采纳,获得10
6秒前
7秒前
7秒前
平常的高跟鞋完成签到 ,获得积分10
7秒前
ju完成签到,获得积分10
7秒前
潘嫄发布了新的文献求助10
7秒前
orixero应助yy采纳,获得10
8秒前
仙林AK47完成签到,获得积分10
9秒前
小文发布了新的文献求助150
9秒前
10秒前
11秒前
11秒前
东方三问应助Duke采纳,获得10
11秒前
CodeCraft应助Charles采纳,获得10
13秒前
13秒前
CipherSage应助Doctor-C采纳,获得10
13秒前
shm123321发布了新的文献求助10
14秒前
董光辉发布了新的文献求助10
16秒前
16秒前
17秒前
17秒前
18秒前
18秒前
阳光珍发布了新的文献求助10
18秒前
19秒前
li发布了新的文献求助10
19秒前
高分求助中
【请各位用户详细阅读此贴后再求助】科研通的精品贴汇总(请勿应助) 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 500
Maritime Applications of Prolonged Casualty Care: Drowning and Hypothermia on an Amphibious Warship 500
Comparison analysis of Apple face ID in iPad Pro 13” with first use of metasurfaces for diffraction vs. iPhone 16 Pro 500
Towards a $2B optical metasurfaces opportunity by 2029: a cornerstone for augmented reality, an incremental innovation for imaging (YINTR24441) 500
Robot-supported joining of reinforcement textiles with one-sided sewing heads 490
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4062746
求助须知:如何正确求助?哪些是违规求助? 3601320
关于积分的说明 11437647
捐赠科研通 3324602
什么是DOI,文献DOI怎么找? 1827742
邀请新用户注册赠送积分活动 898299
科研通“疑难数据库(出版商)”最低求助积分说明 818965