生物
泛素连接酶
细胞生物学
有丝分裂
第1周
泛素
有丝分裂出口
泛素蛋白连接酶类
降级(电信)
细胞周期蛋白
遗传学
主轴装置
细胞周期
细胞分裂
细胞凋亡
细胞
计算机科学
基因
电信
细胞周期蛋白依赖激酶1
作者
Anthony M. Smith,Scott Simanski,Mohammad Fallahi,Nagi G. Ayad
出处
期刊:Cell Cycle
[Informa]
日期:2007-11-15
卷期号:6 (22): 2795-2799
被引量:44
摘要
The irreversible nature of mitotic entry is due to the activation of mitosis specific kinases such as cdk1/cyclin B. Cdk1/cyclin B induces activation of mitosis by promoting phosphatases while suppressing inhibitory factors such as the tyrosine kinase wee1. Since wee1 keeps cdk1/cyclin B inactive during the S and G2 phases, its activity must be down-regulated for mitotic progression to occur. One mechanism of suppressing wee1 activity is ubiquitin-dependent proteolysis. Cdk1/cyclin B1 phosphorylates wee1, targeting it for recognition by ubiquitin ligases and subsequent proteasomal degradation. One of the ubiquitin ligases promoting wee1 destruction during mitosis is the SCF(beta-trcp) complex. We demonstrate that this complex, and a second SCF complex containing the F-box protein Tome-1, regulate wee1 degradation during the S and G2 phases of the cell cycle. Therefore, redundant ubiquitin ligase activities promote efficient mitotic entry of eukaryotic cells.
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