医学
子痫前期
内科学
产科
胎盘生长因子
怀孕
胃肠病学
作者
Xin Zeng,Yu Sun,Huixia Yang,Dong Li,Yu-xia Li,Qin-ping Liao,Yan-Ling Wang
标识
DOI:10.1016/j.ajog.2009.07.032
摘要
Objective The objective of the study was to examine the relevance of the soluble form c-Met (sMet) with the clinical risk for severe preeclampsia. Study Design This prospective case-control study was performed by using plasma derived from 44 preeclamptic and 51 uncomplicated pregnant women. Plasma concentration of sMet was measured with specific enzyme-linked immunosorbent assay, and the predictive values were determined based on the receiver-operating characteristic (ROC) curves analysis. Results Plasma s-Met level in normal pregnant women changed in a gestation-dependent manner, peaking at weeks 19-24. In women with severe preeclampsia, the circulating sMet level was significantly lower than that in the gestational stage-matched controls during gestational weeks 15-30. The ROC curve analysis revealed a significant correlation between plasma sMet level and the risk of developing severe preeclampsia. Conclusion Plasma sMet could serve as a potential biomarker for predicting severe preeclampia at early second trimester of pregnancy.
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