化学
酶
生物化学
赖氨酸
立体化学
生物合成
活动站点
功能(生物学)
细菌
抗菌剂
转移酶
计算生物学
组合化学
氨基酸
生物
遗传学
有机化学
作者
Danuta Gillner,Daniel P. Becker,Richard C. Holz
标识
DOI:10.1007/s00775-012-0965-1
摘要
In this review, we summarize the recent literature on dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure–function studies that provide insight into the catalytic mechanism. Crystallographic data have also provided insight into residues that might be involved in substrate and hence inhibitor recognition and binding. These data have led to the design and synthesis of several new DapE inhibitors, which are described along with what is known about how inhibitors interact with the active site of DapE enzymes, including the efficacy of a moderately strong DapE inhibitor.
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