胶束
纳米载体
内体
离解(化学)
细胞质
化学
酰胺
电荷密度
杰纳斯
药物输送
生物物理学
化学工程
纳米技术
材料科学
有机化学
生物化学
细胞
生物
物理
水溶液
工程类
量子力学
作者
Yan Lee,Takehiko Ishii,Horacio Cabral,Hyun Jin Kim,Ji Hun Seo,Nobuhiro Nishiyama,Hiroki Oshima,Kensuke Osada,Kazunori Kataoka
标识
DOI:10.1002/anie.200900064
摘要
Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).
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