自愈水凝胶
原弹性蛋白
材料科学
组织工程
弹性体
弹性(物理)
可扩展性
纳米技术
生物医学工程
弹性蛋白
复合材料
计算机科学
高分子化学
医学
操作系统
病理
作者
Nasim Annabi,Suzanne M. Mithieux,Pınar Zorlutuna,Gulden Camci‐Unal,Anthony S. Weiss,Ali Khademhosseini
出处
期刊:Biomaterials
[Elsevier]
日期:2013-07-01
卷期号:34 (22): 5496-5505
被引量:104
标识
DOI:10.1016/j.biomaterials.2013.03.076
摘要
Elastic tissue equivalence is a vital requirement of synthetic materials proposed for many resilient, soft tissue engineering applications. Here we present a bioelastomer made from tropoelastin, the human protein that naturally facilitates elasticity and cell interactions in all elastic tissues. We combined this protein's innate versatility with fast non-toxic fabrication techniques to make highly extensible, cell compatible hydrogels. These hydrogels can be produced in less than a minute through photocrosslinking of methacrylated tropoelastin (MeTro) in an aqueous solution. The fabricated MeTro gels exhibited high extensibility (up to 400%) and superior mechanical properties that outperformed other photocrosslinkable hydrogels. MeTro gels were used to encapsulate cells within a flexible 3D environment and to manufacture highly elastic 2D films for cell attachment, growth, and proliferation. In addition, the physical properties of this fabricated bioelastomer such as elasticity, stiffness, and pore characteristics were tuned through manipulation of the methacrylation degree and protein concentration. This photocrosslinkable, functional tissue mimetic gel benefits from the innate biological properties of a human elastic protein and opens new opportunities in tissue engineering.
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