A comparative evaluation of indomethacin, acetaminophen and placebo as antipyretic agents in children

Abstract Two hundred and twenty‐three infants and children with rectal temperatures greater than 101° due to diseases commonly encountered in pediatric practice, were given indomethacin suspension, indomethacin placebo or acetaminophen elixir in a random coded manner according to prescribed dosage schedules. The mean temperature reduction in those groups treated with indomethacin and acetaminophen was statistically significantly better than placebo, and a significant difference in temperature reduction was found between indomethacin and acetaminophen with indomethacin being superior.