儿茶酚胺能
交感神经系统
原发性高血压
医学
背景(考古学)
内分泌学
多巴胺
内科学
高血压的病理生理学
血压
儿茶酚胺
生物
古生物学
出处
期刊:Baillière's clinical endocrinology and metabolism
[Elsevier]
日期:1993-04-01
卷期号:7 (2): 415-438
被引量:21
标识
DOI:10.1016/s0950-351x(05)80182-x
摘要
Given the uibiquitous distribution of catecholamines in mammals, and their importance in a range of physiological processes pivotal to blood pressure regulation, the subject of catecholamines and essential hypertension has a broader context than simply consideration of sympathetic nervous system and adrenal medullary dysfunction. These further matters are the likely involvement in hypertension pathogenesis of the CNS catecholaminergic neurones influencing peripheral sympathetic outflow, the possible pathogenetic significance of adrenaline released as a contransmitter in sympathetic nerves, and the natriuretic renal tubular dopamine mechanisms for regulating body sodium balance which appear to be impaired in patients with essential hypertension. The central consideration, however, remains the important issue of the causes and consequences of the now well-documented sympathetic nervous overactivity which characterizes the early developmental phases of essential hypertension.
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