生物
糖蛋白130
酪氨酸磷酸化
肿瘤抑制因子
转录因子
白血病抑制因子
分子生物学
信号转导
磷酸化
干扰素调节因子
细胞生物学
基因
车站3
细胞因子
遗传学
白细胞介素6
作者
Shizuo Akira,Shin Nishio,Masahiro Inoue,Xuejie Wang,Shi We,Taiji Matsusaka,Kyotaro Yoshida,Tetsuo Sudo,Masanobu Naruto,Tadamitsu Kishimoto
出处
期刊:Cell
[Elsevier]
日期:1994-04-01
卷期号:77 (1): 63-71
被引量:955
标识
DOI:10.1016/0092-8674(94)90235-6
摘要
Acute-phase response factor (APRF) is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. We report here the purification and cloning of APRF. APRF exhibits a 52.5% overall homology at the amino acid level with p91, a component of the interferon (IFN)-stimulated gene factor 3 complexes. The cloned APRF protein is tyrosine phosphorylated and translocated into the nucleus in response to IL-6, but not in response to IFN-gamma. Tyrosine phosphorylation was also observed in response to other cytokines, such as leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor, whose receptors share the IL-6 receptor signal transducer gp130. In contrast, we observed that p91 is not tyrosine phosphorylated in response to IL-6. These results suggest that this novel p91-related protein may play a major role in the gp130-mediated signaling pathway and that selective activation of p91-related factors may explain the diversity of cellular responses to different cytokines.
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