结肠镜检查
乙状结肠镜检查
癌症
粪便潜血
肿瘤科
胃肠病学
癌症筛查
直肠
作者
Esmée J. Grobbee,M van der Vlugt,A J van Vuuren,An K. Stroobants,M.W. Mundt,Wolfert Spijker,Evelien Bongers,E. J. Kuipers,Iris Lansdorp-Vogelaar,Patrick M.M. Bossuyt,E. Dekker,M C W Spaander
出处
期刊:Gut
[BMJ]
日期:2017-11-01
卷期号:66 (11): 1975-1982
被引量:38
标识
DOI:10.1136/gutjnl-2016-311819
摘要
Objective Colorectal cancer screening programmes are implemented worldwide; many are based on faecal immunochemical testing (FIT). The aim of this study was to evaluate two frequently used FITs on participation, usability, positivity rate and diagnostic yield in population-based FIT screening. Design Comparison of two FITs was performed in a fourth round population-based FIT-screening cohort. Randomly selected individuals aged 50–74 were invited for FIT screening and were randomly allocated to receive an OC -Sensor (Eiken, Japan) or faecal occult blood (FOB)-Gold (Sentinel, Italy) test (March–December 2014). A cut-off of 10 µg haemoglobin (Hb)/g faeces (ie, 50 ng Hb/mL buffer for OC-Sensor and 59 ng Hb for FOB-Gold) was used for both FITs. Results In total, 19 291 eligible invitees were included (median age 61, IQR 57–67; 48% males): 9669 invitees received OC-Sensor and 9622 FOB-Gold; both tests were returned by 63% of invitees (p=0.96). Tests were non-analysable in 0.7% of participants using OC-Sensor vs 2.0% using FOB-Gold (p Conclusions The OC-Sensor and FOB-Gold were equally acceptable to a screening population. However, FOB-Gold was prone to more non-analysable tests. Comparison between FIT brands is usually done at the same Hb stool concentration. Our findings imply that for a fair comparison on diagnostic yield between FIT9s positivity rate rather than Hb concentration should be used. Trial registration number NTR5385; Results.
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