To study the influence of polysaccharides of Aloe vera L. on the activity of immune regulate factor in erythrocytes of mice bearing S_(180). The rsults showed that polysaccharides of Aloevera L. can obviously improve red cell immune function through increasing RFED and decrease RFIR in serum of mice bearing S_(180). From the angle of red cell immunity to announce the antitumor mechanism and improve immune of body in polysaccharides of Aloe vera L.