In plants,calcium is taken as the ubiquitous second messenger.Its sensor CBL(calcineurin B-like protein)and CBL-interacting protein kinase(CIPK)integrate into the CBL-CIPK pathway,which plays significant roles in transmitting specific calcium signals in vivo.Generally,as natural living-forms,plants are not affected by only one environmental condition but several of them simultaneously.Therefore,they have to perceive and transmit those simultaneous signals at the same time.Luckily,the specificities of CBL and CIPK in structure,expression and function provide molecular basis on transducting signals specifically.Here,we first presented basic information about CBL and CIPK,and then focused on reviewing the molecular mechanisms of transducting specific Ca2+ signals by CBL-CIPK pathway.