Studies on mouse hyperuricemia model

AIM To establish hyperuricemia animal model. METHODS The mice were given uric acid by ip and then the level of uric acid in serum was detected. RESULTS Uric acid 125,250,500, 1 000 mg·kg -1 ip significantly increased the level of uric acid in mouse serum. The level of uric acid in mouse serum was attained peak at 10 min and the hyperuricemia could lasted over 4 hours after uric acid 250 mg·kg -1 given. CONCLUSION Uric acid given by ip can form mouse hyperuricemia model, the dosage of 250 mg·kg -1 is better.