Objective:to find out the essence of the traditional Chinese medicine properties from detecting the rats'monoamine neurotransmitter after given different traditional Chinese drug. Methods:the property of rhizome curcumae and radix curcumae are opposite,they were given to rats respectively for one month. then use HPLC-ECD method detect the rats' monoamine neurotransmitter in different encephalic region. Results:rhizome curcumae can raise the rats' monoamine neurotransmitter but radix curcumae inhibitor the rats' monoamine neurotransmitter. Conclusion:there are some dependbilitie between the traditional Chinese medicine properties and monoamine neurotransmitter.