Objective To investigate the clinical value of high sensitive C-reactive protein(hs-CRP)in septic knee.Methods The results of hs-CRP,erythrocyte sedimentation rate (ESR),white blood cell count(WBC),neutrophile granulocyte percentage (NGP) of 46 septic knee cases were compared and analyzed retrospectively.Results The sensitivity of hs-CRP was higher than WBC and NGP,not higher than ESR.The same as other examinations,the levels of hs-CRP had not significant difference between the patients with different degree of synovial infection.None of the four examinations showed significant difference when symptoms relieve.There was weak positive linear correlation between hs-CRP and ESR.Conclusion High sensitive C-reactive protein doesn’t show higher clinical value in septic knee.