In Niuquanhu oil field,there exists a low-porosity and ultra-low permeability reservoir with low pressure,in which deliverability of producer was low so that it unsatisfied economically even if enhanced recovery methods such as fracturing and drilling horizontal well were carried out.With the advanced study,through the water-drive development method of advancing water injection and assisting enhanced recovery methods,relatively high formation energy was maintained and strong productivity of the oil wells was improved in a long period.The method of advance water injection maximize the development economic benefit of the ultra-low permeability reservoirs in Xisanyao formation in Niuquanhu oil field.