Lung cancer risk in new pulmonary nodules: implications for CT screening and nodule management

The Dutch-Belgian Randomised Lung Cancer Screen Trial (NELSON) 1 Horeweg N van Rosmalen J Heuvelmans MA et al. Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening. Lancet Oncol. 2014; 15: 1332-1341 Summary Full Text Full Text PDF PubMed Scopus (347) Google Scholar of low-dose CT versus usual care has provided unique evidence about the risk of lung cancer in pulmonary nodules according to semiautomated measurement of the volume of a nodule, calculated diameter, and growth rate expressed as volume doubling time. The study findings have provided an evidence base for the management of pulmonary nodules in the setting of screening programmes and clinical practice. Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trialOur study shows that new solid nodules are detected at each screening round in 5–7% of individuals who undergo screening for lung cancer with low-dose CT. These new nodules have a high probability of malignancy even at a small size. These findings should be considered in future screening guidelines, and new solid nodules should be followed up more aggressively than nodules detected at baseline screening. Full-Text PDF