Deciphering CD4+ Naive T cell-mediated divergent pathogenic links between type 2 diabetes and pathologic scarring via an integrated multi-omics approach

Convergent multi-omics evidence supports the hypothesis that T2D exerts opposing causal effects on different forms of pathological scarring, potentially mediated through CD4+ NT. The transcriptomic features, intercellular communication profiles, key gene signatures, and metabolic landscape of this subset collectively suggest that T2D may contribute to divergent fibrotic pathways in HS and keloids via immune microenvironmental modulation.