Hepatic soluble epoxide hydrolase mediates osteoclastogenesis by suppressing the Nrf2 signaling pathway: a novel mechanism of redox imbalance in osteoporosis

This study reveals, for the first time, a novel regulatory mechanism of bone metabolism mediated by the "liver-bone axis." Liver-derived sEH remotely modulates the Nrf2-ARE signaling pathway in bone tissue by controlling circulating levels of 14,15-EET, 14,15-DHET, and pro-inflammatory cytokines, thereby influencing osteoclast differentiation and bone homeostasis. These findings provide new insights into the pathogenesis of osteoporosis.