瓜尔胶
溃疡性结肠炎
益生菌
医学
醋酸
多糖
结肠炎
药理学
胃肠病学
化学
内科学
生物
病理
生物化学
疾病
细菌
遗传学
作者
Souvik Mohanta,Sachin Kumar Singh,Bimlesh Kumar,Monica Gulati,Rajesh Kumar,Ankit Yadav,Sheetu Wadhwa,Jivan Jyoti,Sananda Som,Kamal Dua,Narendra Kumar Pandey
标识
DOI:10.1016/j.ijbiomac.2018.12.154
摘要
Modified Apple Polysaccharide (MAP) has been reported to cure colorectal diseases by up-regulating apoptosis and down regulating metastasis. In the present study, mesalamine (MES) and MAP mini tablets have been prepared and co-administered with probiotics to provide site specific release of drug. Probiotics along with MAP, which acts as a prebiotic would replenish the colonic microflora that have been compromised due to colorectal pathology. MES mini tablets were prepared keeping guar gum in the core and coating them with Eudragit S100 and guar gum. The optimized batch was explored for its curative potential on acetic acid induced ulcerative colitis (UC) in rat model with and without administration of probiotic and MAP. The results revealed that the rats treated with the combination of MAP and MES mini tablets along with probiotics show maximum curative potential. It was also observed that MAP mini tablets show better curative potential as compared to probiotics. The results of disease activity index, macroscopic scoring, antioxidant studies, tumour alpha and histopathological examination suggested that the rats treated with combination of MES-MAP mini tablets and probiotics have maximum therapeutic effect followed by MES mini tablets alone, MAP mini tablets alone and probiotics.
科研通智能强力驱动
Strongly Powered by AbleSci AI