心情
计算机科学
情绪障碍
心理学
认知心理学
解码方法
癫痫
神经科学
情感(语言学)
编码(内存)
神经解码
临床心理学
沟通
精神科
算法
焦虑
作者
Omid G. Sani,Yuxiao Yang,Morgan B. Lee,Helen Dawes,Edward F. Chang,Maryam M. Shanechi
摘要
Mood state changes are decoded using human neural activity data from electrodes implanted in seven epilepsy patients. The ability to decode mood state over time from neural activity could enable closed-loop systems to treat neuropsychiatric disorders. However, this decoding has not been demonstrated, partly owing to the difficulty of modeling distributed mood-relevant neural dynamics while dealing with the sparsity of mood state measurements. Here we develop a modeling framework to decode mood state variations from multi-site intracranial recordings in seven human subjects with epilepsy who self-reported their mood state intermittently over multiple days. We built dynamic neural encoding models of mood state and corresponding decoders for each individual and demonstrated that mood state variations over time can be decoded from neural activity. Across subjects, the decoders largely recruited neural signals from limbic regions, whose spectro-spatial features were tuned to mood variations. The dynamic models also provided an analytical tool to compute the timescales of the decoded mood state. These results provide an initial line of evidence indicating the feasibility of mood state decoding.
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