The Frequency of Qtc Prolongation Among Pediatric Patients Receiving Methadone for Cancer Pain

Background and Objectives A prolonged corrected QT (QTc) interval in pediatric patients is defined as ≥ 470 milliseconds (msec). Methadone has been reported to cause prolongation of the QTc interval which can lead to ventricular arrhythmias. The risk of methadone-induced prolongation of the QTc interval in children is unknown. There is only one case report of methadone-induced prolongation of the QTc interval in a child who received intravenous and …