溶解度
生物利用度
生物制药
肠道通透性
化学
肺表面活性物质
材料科学
色谱法
磁导率
化学工程
有机化学
药理学
医学
生物化学
生物技术
工程类
膜
免疫学
生物
作者
Nidhi Nainwal,Ranjit Singh,Sunil Jawla,Vikas Anand Saharan
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2019-10-14
卷期号:20 (14): 1434-1446
被引量:9
标识
DOI:10.2174/1389450120666190717114521
摘要
The Biopharmaceutical classification system (BCS) classifies the drugs based on their intrinsic solubility and intestinal permeability. The drugs with good solubility and intestinal permeability have good bioavailability. The drugs with poor solubility and poor permeability have solubility dependent and permeability dependent bioavailability, respectively. In the current pharmaceutical field, most of the drugs have poor solubility. To solve the problem of poor solubility, various solubility enhancement approaches have been successfully used. The effects of these solubility enhancing approaches on the intestinal permeability of the drugs are a matter of concern, and must not be overlooked. The current review article focuses on the effect of various solubility enhancing approaches viz. cyclodextrin, surfactant, cosolvent, hydrotropes, and amorphous solid dispersion, on the intestinal permeability of drugs. This article will help in the designing of the optimized formulations having balanced solubility enhancement without affecting the permeability of drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI