光动力疗法
化学
卟啉
双光子激发显微术
赫拉
单线态氧
共轭体系
光化学
二聚体
分子
磁共振成像
结合
核磁共振
荧光
光学
细胞
放射科
氧气
数学分析
聚合物
有机化学
物理
医学
生物化学
数学
作者
Julie Schmitt,Sébastien Jenni,Angélique Sour,Valérie Heitz,Frédéric Bolze,Agnès Pallier,Célia S. Bonnet,Éva Tóth,Barbara Ventura
标识
DOI:10.1021/acs.bioconjchem.8b00634
摘要
A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance imaging (MRI) is reported. It consists of a linear π-conjugated Zn(II) porphyrin dimer linked at each extremity to a GdDOTA-type complex. This agent has shown very promising potential for PDT applications with good singlet oxygen generation in DMSO and high linear absorption in the near-infrared (λmax = 746 nm, ε ≈ 105 M-1 cm-1). Moreover, this molecule has a propensity for two-photon excited PDT with high two-photon cross sections (∼8000 GM in 880-930 nm range), which should allow for deeper tumor treatments and higher spatial precision as compared to conventional one-photon PDT. Regarding the MRI contrast agent properties, the molecule has shown superior relaxivity (14.4 mM-1 s-1 at 40 MHz, 298 K) in comparison to clinical contrast agents and the ability to be internalized in cells, thanks to its amphiphilic character. Irradiation of HeLa cells using either one-photon (740 nm) or two-photon excitation (910 nm) has led in both cases to important cell death.
科研通智能强力驱动
Strongly Powered by AbleSci AI