Ring-opening Addition Reactions of 1-tert-Butoxycarbonyl-3,4- epoxypiperidine with Amine Nucleophiles

Ring-opening addition reactions of 1-tert-butoxycarbonyl-3,4-epoxypiperidine leading to the formation of the corresponding regioisomeric trans-β -aminoalcohols were carried out with three different types of amine nucleophiles under different reaction conditions with a view to study the reactivity and regioselectivity.