Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistanceviaglucagon‐like peptide 1 in diet‐induced obesity

厚壁菌 拟杆菌 胰岛素抵抗 肠道菌群 杆菌肽 生物 微生物学 能量稳态 高胰岛素血症 内分泌学 胰岛素 肥胖 抗生素 免疫学 生物化学 16S核糖体RNA 基因
作者
Injae Hwang,Yoon Jeong Park,Yeon‐Ran Kim,Yo Na Kim,Sojeong Ka,Ho‐Young Lee,Je Kyung Seong,Yeong‐Jae Seok,Jae Bum Kim
出处
期刊:The FASEB Journal [Wiley]
卷期号:29 (6): 2397-2411 被引量:191
标识
DOI:10.1096/fj.14-265983
摘要

Firmicutes and Bacteroidetes, 2 major phyla of gut microbiota, are involved in lipid and bile acid metabolism to maintain systemic energy homeostasis in host. Recently, accumulating evidence has suggested that dietary changes promptly induce the alteration of abundance of both Firmicutes and Bacteroidetes in obesity and its related metabolic diseases. Nevertheless, the metabolic roles of Firmicutes and Bacteroidetes on such disease states remain unclear. The aim of this study was to determine the effects of antibiotic-induced depletion of Firmicutes and Bacteroidetes on dysregulation of energy homeostasis in obesity. Treatment of C57BL/6J mice with the antibiotics (vancomycin [V] and bacitracin [B]), in the drinking water, before diet-induced obesity (DIO) greatly decreased both Firmicutes and Bacteroidetes in the gut as revealed by pyrosequencing of the microbial 16S rRNA gene. Concomitantly, systemic glucose intolerance, hyperinsulinemia, and insulin resistance in DIO were ameliorated via augmentation of GLP-1 secretion (active form; 2.03-fold, total form; 5.09-fold) independently of obesity as compared with untreated DIO controls. Furthermore, there were increases in metabolically beneficial metabolites derived from the gut. Together, our data suggest that Firmicutes and Bacteroidetes potentially mediate insulin resistance through modulation of GLP-1 secretion in obesity.—Hwang, I., Park, Y. J., Kim, Y. -R., Kim, Y. N., Ka, S., Lee, H. Y., Seong, J. K., Seok, Y.-J., Kim, J. B. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J. 29, 2397-2411 (2015). www.fasebj.org
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