STUDY OF PROTEASES AND PROTEASE INHIBITORS FROM STREPTOMYCES STRAINS

Proteases and protease inhibitors are important enzymes in Streptomyces physiology and differentiation. The objectiveof this paper was to investigate the optimal conditions for production of proteases and protease inhibitors secreted by threenewly isolated Streptomyces strains. The optimal growth and inhibition activities were detected after cultivation on differentmedia and the maximum of protease inhibition activities were specifi c for the examined strains. The extracellular proteins werepurifi ed by ammonium sulfate precipitation and SDS-PAGE. One of the examined strains showed protease inhibitory activityperspective for future research.