拉曼光谱
光谱学
生物分子
材料科学
去极化率
分析化学(期刊)
去极化
化学
核磁共振
光学
纳米技术
生物物理学
物理
色谱法
量子力学
生物
作者
Amuthachelvi Daniel,Prakasarao Aruna,Dornadula Koteeswaran,Singaravelu Ganesan
标识
DOI:10.1016/j.saa.2015.06.053
摘要
Polarized Raman spectroscopy has emerged as a promising technique giving a wealth of information about the orientation and symmetry of bond vibrations in addition to the general chemical information from the conventional Raman spectroscopy. In this regard, polarized Raman Spectroscopic technique was employed to study the changes in the orientation of biomolecules in normal and cancerous conditions. This technique was compared to the conventional Raman spectroscopic technique and was found to yield additional information about the orientation of tyrosine, collagen and DNA. The statistically analyzed depolarization ratios by Linear Discriminant Analysis yielded better accuracy than the statistical results of conventional Raman spectroscopy. Thus, this study reveals that polarized Raman spectroscopy has better diagnostic potential than the conventional Raman spectroscopic technique.
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