生物
微生物群
免疫学
失调
菌类
癌变
肠道菌群
微生物学
细胞生物学
癌症研究
癌症
结直肠癌
遗传学
生态学
作者
Nicolas Papon,Gordon D. Brown,Neil A. R. Gow
标识
DOI:10.15252/embj.2021108175
摘要
While there is growing evidence that perturbation of the gut microbiota can result in a variety of pathologies including gut tumorigenesis, the influence of commensal fungi remains less clear. In this issue, Zhu et al (2021) show that mycobiota dysbiosis stimulates energy metabolism changes in subepithelial macrophages promoting colon cancer via enhancing innate lymphoid cell activity. These findings provide insights into a role of the gut flora in intestinal carcinogenesis and suggest opportunities for adjunctive antifungal or immunotherapeutic strategies to prevent colorectal cancer.
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