医学
体内
链脲佐菌素
种植周围炎
吸收
糖尿病
牙科
骨吸收
炎症
病理
植入
内科学
2型糖尿病
内分泌学
外科
生物
生物技术
作者
Qingqing He,Zhixiang Mu,Annie Shrestha,Chao Wang,Si Wang,Han Tang,Yihan Li,Jinlin Song,Ping Ji,Yuanding Huang,Tao Chen
出处
期刊:Oral Diseases
[Wiley]
日期:2021-05-06
卷期号:28 (7): 1936-1946
被引量:11
摘要
To develop an in vivo model to simulate the complex internal environment of diabetic peri-implantitis (T2DM-PI) model for a better understanding of peri-implantitis in type 2 diabetic patients.Maxillary first molars were extracted in Sprague-Dawley (SD) rats, and customized cone-shaped titanium implants were installed in the extraction sites. Thereafter, implants were uncovered and customized abutments were screwed into implants. A high-fat diet and a low-dose injection of streptozotocin were utilized to induce T2DM. Finally, LPS was locally injected in implant sulcus to induce peri-implantitis.In the present study, T2DM-PI model has been successfully established. Imaging analysis revealed that abundant inflammatory cells infiltrated in the soft tissue in T2DM-PI group with concomitant excessive secretion of inflammatory cytokines. Moreover, higher expression of MMP and increased number of osteoclasts led to collagen disintegration and bone resorption in T2DM-PI group.These results describe a novel rat model which stimulate T2DM-PI in vivo, characterized by overwhelming inflammatory response and bone resorption. This model has a potential to be used for investigation of initiation, progression and interventional therapy of T2DM-PI.
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