蒽环类
医学
肿瘤科
乳腺癌
化疗
内科学
等位基因
中性粒细胞减少症
胃肠病学
药理学
癌症
生物
遗传学
基因
作者
Liqian Cui,Jia Huang,Yongtao Zhan,Ni Qiu,Huan Jin,Jia Li,Hao Huang,Hongsheng Li
出处
期刊:Life Sciences
[Elsevier]
日期:2021-07-01
卷期号:276: 119392-119392
被引量:5
标识
DOI:10.1016/j.lfs.2021.119392
摘要
Exploring the genetic polymorphisms involved in the metabolism of anthracyclines can explain the causes of individual differences in myelosuppression during anthracycline-based chemotherapy. By PCR and Sanger sequencing, SNP of candidate genes participating into the pharmacokinetics of anthracycline, including chemotherapeutic drug intake (SLC22A16 rs6907567), metabolism (AKR1A1 rs2088102, CBR1 rs20572) and transfer (ABCG2 rs2231142) are detected in 194 breast cancer patients undergoing anthracycline-based postoperative adjuvant chemotherapy. The CBR1 rs20572 (C>T) polymorphic allele, the ABCG2 rs2231142 (G>T) polymorphic allele, or the two polymorphic allele in combination significantly reduced the risk of leukopenia (OR 0.412, 95% CI 0.187–0.905, p = 0.025) and neutropenia (OR 0.354, 95% CI 0.148–0.846, p = 0.018). Either polymorphic allele T of CBR1 rs20572, or polymorphic allele C of AKR1A1 rs2088102 combined with the presence of both ABCG2 rs2231142(G>T) and SLC22A16 rs6907567(A>G) mutations were at extremely low risk of severe anemia of grades 3 and 4 (OR 0.058, 95% CI 0.006–0.554, p = 0.008, OR 0.065, 95% CI 0.006–0.689, p = 0.022, OR 0.037, 95% CI 0.004–0.36, p = 0.015, respectively). These results suggested CBR1 rs20572, ABCG2 rs2231142, SLC22A16 rs6907567 and AKR1A1 rs2088102 might be potential protective factors for the reduction of hematologic toxicity incidence during anthracycline-based chemotherapy in breast cancer patients.
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