药品
药理学
医学
靶向给药
毒品携带者
药代动力学
生化工程
透皮
剂型
输送系统
纳米技术
化学
药物开发
作者
Yajie Zhang,Dan Davis,Khaled AboulFotouh,Jieliang Wang,Donna M. Williams,Akhilesh Bhambhani,Michael Zakrewsky,Mohammed Maniruzzaman,Zhengrong Cui,Robert O. Williams
标识
DOI:10.1016/j.addr.2021.02.011
摘要
Abstract Recent advances in formulation sciences have expanded the previously limited design space for biological modalities, including peptide, protein, and vaccine products. At the same time, the discovery and application of new modalities, such as cellular therapies and gene therapies, have presented formidable challenges to formulation scientists. We explore these challenges and highlight the opportunities to overcome them through the development of novel formulations and drug delivery systems as biological solids. We review the current progress in both industry and academic laboratories, and we provide expert perspectives in those settings. Formulation scientists have made a tremendous effort to accommodate the needs of these novel delivery routes. These include stability-preserving formulations and dehydration processes as well as dosing regimes and dosage forms that improve patient compliance.
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