医学
熊去氧胆酸
脂肪变性
脂联素
非酒精性脂肪肝
内科学
内分泌学
脂肪肝
G蛋白偶联胆汁酸受体
受体
胰岛素抵抗
药理学
胰岛素
疾病
出处
期刊:PubMed
日期:2011-01-01
卷期号: (11): 79-85
被引量:1
摘要
As a signaling molecule with system endocrine function, UDCA improves insulin sensitivity by activating the nuclear farnezoid X-receptor; as a ligand for the TGR5/Gpbar-1 receptor, UDCA is able to stimulate the secretion of GLP-1. UDCA ameliorate of the anti-oxidative defenses in NAFLD, normalizes NAD+/NADH ratio, beta-oxidation. UDCA improves the liver biochemical and histological picture in NASH, also reduces hepatocytes apoptosis and restores adiponectin levels; in other studies, these data are not confirmed. In the experiment, UDCA prevents the development of steatosis in the liver. UDCA may increase efficiency in combination with statins, thiazolidinediones, vitamin E. Further controlled prospective trials are needed for research of the UDCA effect in NAFLD.
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