Toll样受体
模式识别受体
免疫系统
TLR2型
TLR3型
细胞生物学
医学
促炎细胞因子
作者
Jan Petrasek,Timea Csak,Gyongyi Szabo
出处
期刊:Advances in Clinical Chemistry
日期:2013-01-01
卷期号:59: 155-201
被引量:62
标识
DOI:10.1016/b978-0-12-405211-6.00006-1
摘要
Activation of inflammatory signaling pathways is of central importance in the pathogenesis of alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Recent studies demonstrated that Toll-like receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD and NASH. In this review, we emphasize the importance of gut-derived endotoxin and its recognition by TLR4 in the liver. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of individual cell types to the inflammation is evaluated. The contribution of TLR signaling to the induction of liver fibrosis and to the progression of liver pathology mediated by viral pathogens is reviewed in the context of ALD and NASH.
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