Cytotoxic Effects of Chemotherapy on Cancer and Immune Cells: How can it be Modulated to Generate Novel Therapeutic Strategies?

The first objective to use chemotherapy is to kill cancer cells. However, it is common knowledge that these drugs can also damage healthy host cells, especially immune cells, and thus impair the endogenous antitumor response. Here, we focus on the cytotoxic effects of chemotherapy on tumor cells and immune cells. It is not enough to simply kill cancer cells, and causing immunogenic cell death will impair the adaptive immune system's ability to fight the remaining cancer cells. On the other hand, the killing of immune cells can also enhance tumor growth. A study of the repercussions of the cytotoxic effects of chemotherapy is of great importance to evaluate the antitumor response. Strategies can be proposed to promote the 'good way' for cancer cells to die and to avoid the adverse side effects of chemotherapy on immune cells in order to strengthen the role of the immune system in the antitumor response.