医学
危险分层
地中海贫血
移植
分层(种子)
不利影响
干细胞
内科学
肿瘤科
遗传学
休眠
植物
生物
种子休眠
发芽
作者
Vikram Mathews,Biju George,Uday Deotare,Kavitha M Lakshmi,Auro Viswabandya,Dolly Daniel,Mammen Chandy,Alok Srivastava
标识
DOI:10.1016/j.bbmt.2007.05.004
摘要
One hundred ninety patients underwent 197 HLA-matched related allogeneic stem cell transplantation for a diagnosis of beta thalassemia major at our center. The median age (+/-SD) was 7+/-4.1 years, and there were 129 (68%) males. Age and liver size as continuous variables were significantly associated with an adverse outcome. Using a receiver operator characteristics curve plot analysis, cutoff values of 7 years and 5 cm for age and liver size, respectively, were associated with the highest likelihood ratio of an adverse impact. On a multivariate analysis age>or=7 years and liver size>or=5 cm had a significant impact on event free survival (EFS) (relative risk 2.2 and 2.7, P values .014 and .000, respectively). Using these 2 variables, patients were categorized as high risk if they were >or=7 years and had a liver size>or=5 cm (n=41; all belonged to Class III). The 5-year EFS and overall survival (OS) in this high-risk group was 23.93+/-6.88 and 39.01+/-7.96, whereas in the remaining Class III patients (n=64) it was 70.3+/-6.06 and 78.3+/-5.5, respectively. This risk stratification identifies a significant subset (39%) of patients among those in Class III who have a poor outcome with a conventional myeloablative allogeneic stem cell transplantation. Patients in this high-risk group would probably benefit from novel therapeutic approaches.
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