Abdominal Aortic Aneurysm: Still No Pill

Editorials17 December 2013Abdominal Aortic Aneurysm: Still No PillFrank A. Lederle, MDFrank A. Lederle, MDFrom Veterans Affairs Health Care System, Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-12-201312170-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In 2005, the U.S. Preventive Services Task Force recommended 1-time ultrasonography screening for abdominal aortic aneurysm (AAA) for men aged 65 to 75 years who have ever smoked. The recommendation was based on data from randomized trials that showed a decrease in aneurysm-related mortality rates by screening. The benefit of screening results from prevention of rupture deaths by elective repair of large AAAs. However, randomized trials have found no benefit from elective repair of small AAAs (those less than 5.5 cm in diameter) by either the open or endovascular method (1), and more than 90% of AAAs detected at screening ...References1. Filardo G, Powell JT, Martinez MA, and Ballard DJ. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev. 2012;3:CD001835. [PMID: 22419281] MedlineGoogle Scholar2. Lederle FA, Johnson GR, Wilson SE, Chute EP, Hye RJ, Makaroun MS, et al. The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators. Arch Intern Med. 2000;160:1425-30. [PMID: 10826454] CrossrefMedlineGoogle Scholar3. Bown MJ, Sweeting MJ, Brown LC, Powell JT, and Thompson SG; RESCAN Collaborators. Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis. JAMA. 2013;309:806-13. 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[PMID: 22042930] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Frank A. Lederle, MDAffiliations: From Veterans Affairs Health Care System, Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-2554.Corresponding Author: Frank A. Lederle, MD, Minneapolis Veterans Affairs Health Care System, Center for Chronic Disease Outcomes Research, 1 Veterans Drive (111-O), Minneapolis, MN 55417; e-mail, [email protected]. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDoxycycline for Stabilization of Abdominal Aortic Aneurysms C. Arnoud Meijer , Theo Stijnen , Martin N.J.M. Wasser , Jaap F. Hamming , J. Hajo van Bockel , and Jan H.N. Lindeman , for the Pharmaceutical Aneurysm Stabilisation Trial Study Group* Metrics 17 December 2013Volume 159, Issue 12 Page: 852-853 Keywords Adverse events Aneurysms Antibiotics Aorta Cells Cerebral arteries Colectomy Coronary arteries Databases Death rates Doxycycline Drugs Enzyme inhibitors Inflammation Interleukins Metalloproteases Observational studies Stable coronary artery disease Statins Ultrasound imaging ePublished: 17 December 2013 Issue Published: 17 December 2013 PDF downloadLoading ...