免疫系统
单核细胞
抗原
免疫学
生物
肿瘤坏死因子α
主要组织相容性复合体
免疫耐受
子宫内膜
树突状细胞
细胞因子
淋巴增殖反应
细胞生物学
男科
体外
医学
外周血单个核细胞
内分泌学
生物化学
作者
Christoph Scholz,Bettina Tóth,Regina Brunnhuber,Elisabeth Rampf,Tobias Weißenbacher,Laura Santoso,Klaus Friese,Udo Jeschke
标识
DOI:10.1111/j.1600-0897.2008.00647.x
摘要
Problem Successful mammalian pregnancy requires a delicate immunological balance at the feto‐maternal interface that allows the semi‐allogeneic fetus to grow, while protecting mother and child from environmental pathogens. As in other mucosal tissues, antigen‐recognition and ‐handling by professional antigen‐presenting cells such as dendritic cells (DC) determine the course of the subsequent immune response. DC at the feto‐maternal interface help shape this immunological equilibrium. Endometrial tissue secretes high quantities of glycodelin A (GdA) during the so‐called fertile window (i.e. the time of implantation of the blastocyst). Method of study We investigated the effect of GdA on monocyte‐derived DC (moDC) regarding surface marker expression, endopinocytotic activity, cytokine profile as well as lymphoproliferative activity. Results Upon pretreatment with GdA and subsequent maturation with tumor necrosis factor‐α and interleukin (IL)‐1β, moDC displayed a reduced expression of costimulatory molecules, an unchanged major histocompatibility complex‐II expression and persistence of DC‐SIGN positive cells. GdA‐pretreated moDC had a higher endopinocytotic activity, an increased IL‐10 production and a dose‐dependent reduction in lymphoproliferative activity. GdA incubation alone did not alter the immature phenotype. Conclusion Our results suggest a model in which the human endometrium secretes high quantities of GdA during implantation and thereby helps to shape the unique immunological interaction between mother and fetus via decidual DC.
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